Human Toxicology and the British Toxicology Society—a closer association

Pharmacology and Toxicology of Leflunomide

Leflunomide (LEF), used for rheumatoid arthritis, inhibits dihydro-orotate dehydrogenase (DHODH) and tyrosine kinase (TK) enzymes and has anti-inflammatory, lymphocyte proliferation regulatory, immunosuppression and chondroprotective effects. The most common adverse effects are gastrointestinal disorders, weight loss, hypertension, skin infection, and neurological and hematological toxicity. It...

Studies Genetic Toxicology and Human

the Journal of Craniofacial Genetics and Developmental Biology, 1985, vol 5, is dedicated to the memory of Dr Samuel Pruzansky, an internationally renowned worker in the field of craniofacial malformations until his death in 1984. Among his many achievements, Dr Pruzansky organised the first international symposium on craniofacial malformations in 1959 and founded the first Center for Craniofac...

ENVIRONMENTAL TOXICOLOGY AND HUMAN HEALTH – Forensic Toxicology – Robert WENNIG ©Encyclopedia of Life Support Systems (EOLSS) FORENSIC TOXICOLOGY

The human toxicology of dimethyl sulfoxide.

On November 11, 1965, research on DMSO in the United States came to an abrupt halt. A conference between the Food and Drug Administration and the pharmaceutical companies who were involved in the research was called because lens changes had been observed in a number of mammalian species. No changes ha been observed in man or any primates. The FDA and the pharmaceutical companies agreed, because...

Toxicology. Arsenic victims to take British science body to court.

1066 C RE D IT S: (T O P TO B O TT O M ) PA V EL R A H M A N /A P; D .M A C K EN Z IE CAMBRIDGE, U.K.—The British Geological Survey (BGS) is girding for a court battle over claims that it could have averted a wave of arsenic poisoning in Bangladesh over the past decade. A High Court judge in London last week gave the go-ahead for a trial pitting two Bangladeshi residents against BGS’s parent bo...